2nd International “Michele Baccarani” Conference

First day - 22/03/2024

14.00-14.15 Presentation of the Meeting

Giuseppe Saglio, Domenico Russo, Nicola Polverelli

14.15-15.45 Session 1 - CML Biology: What’s new

Chairmen: Giovanni Martinelli, Giorgina Specchia

-                  How searching Ph+ LSC (15 Min)Monica Bocchia

-                  Genetic instability of Ph+ LSC: primary vs secondary (15 Min) Simona Soverini

-                  Added value of next generation over Sanger sequencing to determine outcome after resistance to first line   TKI therapy (15 Min) Anna Vedovati

-                  How monitoring BCR/ABL1 transcript (15 Min) Simona Bernardi

-                  How targeting Ph+ LSC (15 Min) Daniela Cilloni

-                  Zebrafish for testing efficacy and safety of TKIs (15 Min) Daniela Zizioli

15.45-16.15 Coffee break

16.15-17.15 CML Session 2: Advances in CML treatment in Europe

Chairmen: Susanne Saussele, Fabrizio Pane

-                  In Italy (20 Min) Fausto Castagnetti

-                  In France (20 Min) Philippe Rousselot

-                  In Germany (20 Min) Susanne Saussele

17.15-19.30 CML Session 3: Moving to personalized CML treatment

Chairmen: Giuseppe Saglio, Domenico Russo    

I Part

-                  Is the survival reached for all CML patients - Discussants (20 Min)

Yes - Olga Mulas

No - Mario Tiribelli

-                  What are the new objectives for CML pts? - Discussant (20 Min)

Cure - Fausto Castagnetti

Quality of Life - Michele Malagola

-                  TFR for all? - Discussants (20 Min)

Yes - Carmen Fava

No - Alessandra Iurlo

-                  Escalation for eradication - Discussants (20 Min)

Yes - Massimo Breccia

No - Mirko Farina

18.35

II part

Different drug and/or different strategies for different patients?

-        Clinical case 1 (adult 73yy low risk pt) - Discussant (15 min)  Massimiliano Bonifacio

-        Clinical case 2 (adult 37yy int risk pt) -   Discussant (15 min)   Antonella Gozzini

-        Clinical case 3 (adult 56yy high risk pt) - Discussant (15 min) Roberto Latagliata

Discussion

End of the first day - 19.30

Second day - 23/03/2024

09.00 - 10.30 Session 4 -Driving the future in CML Therapy

Chairmen: Susanne Saussele, Giuseppe Saglio

-                  Combinatorial treatment options for highly resistant BCR::ABL1 compound mutations (20 Min) Thomas Lion

-                  Reduction of TKI dosage in maintenance therapy (20 Min) Michele Malagola

-                  What do we have to fear as Long term Toxicity? (20 Min) Carlo Gambacorti Passerini

-                  What is new in ELN guidelines 2024 (20 Min) Jane Apperley

Discussion

10.30 - 11.00 Coffee Break

11.00 - 11.45 Session 5 - News from Labs

Chairmen: Giovanni Martinelli, Simona Bernardi

-                  New diagnostic and prognostic tools (20 Min) Sara Galimberti

-                  How to move from RTq-PCR to dPCR Labnet (25 Min) Enrico Gottardi and Barbara Izzo

Discussion

12.00 - 13.00 Baccarani Lecture: CML: the story's not over yet! Jane Apperley

13.00 - 14.30 Lunch Break 

14.30 - 15.30 Session 6 - Myelofibrosis: the route to cure

Moderator: Donal McLornan, Nicola Polverelli

-                  2024 updates on risk stratification and medical treatment options (15 Min) Francesca Palandri

-                  New drugs and integrated approaches: is there a need for novel outcome measures? (15 Min) Giuseppe A. Palumbo

-                  Role of transplant in MF in contemporary years: who and when (15 Min) Nico Gagelmann

-                  The importance of cooperative studies: the experience of the Chronic Malignancies Working Party of the EBMT (15 Min) Donal McLornan

15.30 - 16.30 Session 7 - Evolving landscape in Ph- MPNs

Moderator: Nico Gagelmann, Domenico Russo

-                  MPNs: an example of inflammatory disease (15 Min) Alessandro Lucchesi

-                  New biological insights into the pathogenesis and progression of MPNs (15 Min) Paola Guglielmelli

-                  Current management and unmet needs in ET and PV (15 Min) Barbara Mora

End of second day - 16.30

SCARICA IL PROGRAMMA

Organizers:

D. Russo

G. Saglio

N. Polverelli

Scientific Secretariat:

S. Bernardi

M. Malagola

A. Leoni

Faculty

Jane Apperley (London)

Simona Bernardi (Brescia)

Monica Bocchia (Siena)

Massimiliano Bonifacio (Verona)

Massimo Breccia (Roma)

Fausto Castagnetti (Bologna)

Daniela Cilloni (Torino)

Mirko Farina (Brescia)

Carmen Fava (Torino)

Nico Gagelmann (Hamburg)

Sara Galimberti (Pisa)

Carlo Gambacorti Passerini (Monza)

Enrico Gottardi (Torino)

Antonella Gozzini (Firenze)

Paola Guglielmelli (Firenze)

Alessandra Iurlo (Milano)

Barbara Izzo (Napoli)

Roberto Latagliata (Roma)

Thomas Lion (Vienna)

Alessandro Lucchesi (Meldola)

Michele Malagola (Brescia)

Giovanni Martinelli (Meldola)

Donal McLornan (London)

Barbara Mora (Milano)

Olga Mulas (Cagliari)

Francesca Palandri (Bologna)

Giuseppe A. Palumbo (Catania)

Fabrizio Pane (Napoli)

Nicola Polverelli (Pavia)

Philippe Rousselot (Le Chesnay)

Domenico Russo (Brescia)

Giuseppe Saglio (Torino)

Susanne Saussele (Mannheim)

Simona Soverini (Bologna)

Giorgina Specchia (Bari)

Mario Tiribelli (Udine)

Anna Vedovati (Brescia)

Daniela Zizioli (Brescia)

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